Di:phenyl phosphinyl acetic acid hydrazide as pharmaceutical - to treat psychic and nervous disorders esp. epilepsy

摘要

A pharmaceutical with excellent vehetotropic and antieliptic activities and which can be used in the treatment of psychic and nervous disorders, contains diphenyl phosphinyl acetic acid hydrazide of formula: Ph2P(=O)CH2-C(=O)NHH2 (I) and a filler. (I) are relatively weak tranquilisers, and the main effect is on the centres of vegetative regulation in the hypothalamic and edge structures of the brain, in which the epileptogenic centre in temporal epilepsy is situated. (I) also protects against the group toxicity of phenamine (aphetamine). (I) causes no local irritation and is of low toxicity (LD5o for mice is 293 mg/kg i.v.). Suitable daily doses are 1.0-3.0 g (taken in units of 0.5-1.0g, 2 to 3 times daily). The treatment takes 1 week to 1 1/2 to 2 months and in temporal epilepsy up to 3-5 months.