摘要 |
<p>The present invention relates to an improvement in the process for preparing 7-(1H-tetrazol-1-yl)acetamido-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid (cefazolin) by reacting a solvate of N,Ndimethylformamide and the hydrochloride salt of 7-amino-3- (2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-car-boxylic acid with 1H-tetrazole-1-acetyl chloride in the presence of N,N-dimethylacetamide as solvent. Cefazolin is a useful antibiotic.</p> |