MEJORAS INTRODUCIDAS EN EL OBJETO DE LA PATENTE PRINCIPAL N. 439.235 PRESENTADA EL 8.7.75, POR: PROCEDIMIENTO PARA LA PREPARACION DE BUFADIENOLID-ETERES Y BUFATRIENOLID-ETERES

摘要

Bufadienolide or bufatrienolide ethers of the formula I are prepared by reaction of the corresponding bufadienolide glycoside or bufatrienolide glycoside with a diazoalkane. The reaction is carried out in an inert solvent in the presence of a mixture, which serves as a catalyst, of titanium tetrachloride and boric acid or of titanic acid ester and titanium tetrachloride or titanic acid ester on its own in absolute dioxane. The symbols in formula I have the meaning given in Claim 1. The compounds of the formula I are employed in the therapy of heart disorders.