3-Thia-13-trans-prostenoic acid derivs. - useful as selective and long lasting hypotensives, antisecretories, antiulcer agents, contraceptives, CNS regulators, abortifacients, etc.

摘要

Optically active prostaglandin analogues of formula (I), their racemates, mirror images and, when R1 is OH, pharmaceutically acceptable salts, are new. In the formula, n is 3 or 4. R1 is OH or 1-6C alkoxy W is one of the gps. (II)- Q is e.g. -C(CH3)2R6, -CH2C(CH3)2R7 or -CHR6R8; R4 is H or CH3; R5 is 4-7C alkyl; R6 is 3-5C alkyl; R7 is 2-4C alkyl; R8 is 1-2C alkyl. (I) are useful as hypotensives, antiulcer agents, antisecretories, to protect against gastric damage by nonsteroid antiinflammatories, abortifacients, labour- or menstruation-inducers, contraceptives, regulators of oestrus (in animal breeding) and CNS regulators Generally compared with natural PG's they are more selective and/or have a more persistent effect.