1,3-Dithiolane compounds and method of preparation thereof

摘要

There are provided substituted 1,3-dithiolane compounds and a method for preparing the same. Said 1,3-dithiolane compounds are useful intermediates in the preparation of tetrahydro-7-oxobenzo[b]thien-4-ylureas and tetrahydro-4-oxo-1-naphthylureas which are known animal growth-promotong agents, which thiolanes are represented by the formula: <IMAGE> wherein R1 is a member selected from the group consisting of 2-thienyl and phenyl; R2 is a member selected from the group consisting of <IMAGE> wherein X is chlorine or bromine; R3 and R4 are each members selected from the group consisting of hydrogen and methyl; and when R1 and R2 are taken together with the carbon atom to which they are attached they represent a bicyclic moiety selected from the group consisting of <IMAGE> wherein the carbon atom of said bicyclic moiety marked with an asterisk is also part of the 1,3-dithiolene ring; U is a moiety selected from the group consisting of <IMAGE> and when U is <IMAGE> said compounds are the racemic mixtures and the optical isomers thereof.