1125 IMIDAZOLE STEROID DERIVATIVES

摘要

Reagent for radioimmunoassay of steroids is of formula (Z = radioactive isotope, specifically 125I. X = bridging gp. Y = steroid residue). Specified cpds. are of formula (Ia) (Q = cHO and K = H or Q = CH3 and K = OH). Methods for radioimmunoassay of cortisol and aldersterone using (Ie are also claimed. Unline radioiodine-labelled tyrosine derivs. of steroids, (I) have virtually the same reactivity towards antibodies as the unlabelled steroids and do not react non-specifically with the reaction vessel or plasma components.