发明名称 |
DIPHENYLAETHERDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND PHARMAZEUTISCHE ZUBEREITUNGEN ENTHALTEND DIESE VERBINDUNGEN |
摘要 |
New diphenyl ether derivs. are of formula (I) where R1 is F, Cl, Br or Cf3; Y is COOH, COOR2, CH2OH or CH2OAc; R2 is not >8C alkyl or aryl; and Ac is 1-8C acyl) and their salts. Specific (I) include 3-(4-(4-chlorophenoxy)phenyl)-methacrylic acid. In an example, this is prepd. by boiling 3-(4-(4-chlorophenoxy)phenyl)methacrylonitrile with EtOH, water and KOH. (I) have thrombocyte aggregation inhibiting activity, and also show fibrinolytic, and cholesterol- and triglyceride-lowering properties. (I) are also useful as intermediates for other pharmaceuticals. |
申请公布号 |
DE2709268(A1) |
申请公布日期 |
1978.09.07 |
申请号 |
DE19772709268 |
申请日期 |
1977.03.03 |
申请人 |
MERCK PATENT GMBH |
发明人 |
SCHACHT,ERICH,DIPL.-CHEM.DR.;GANTE,JOACHIM,DIPL.-CHEM.DR.;KURMEIER,HANS-ADOLF,DIPL.-CHEM.DR.;ORTH,DIETER,DIPL.-CHEM.DR.;MAISENBACHER,JUERGEN,DIPL.-CHEM.DR.;LISSNER,REINHARD,DR. |
分类号 |
C07C69/734;A61K31/085;A61K31/19;A61K31/215;A61K31/22;A61P7/02;C07C41/00;C07C43/29;C07C43/295;C07C51/00;C07C59/66;C07C59/68;C07C67/00;C07C69/025;C07C69/618 |
主分类号 |
C07C69/734 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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