PROCEDE POUR LA PREPARATION DE MICRO-SPHERES COMPOSEES D'UN MATERIEL POLIMERIQUE ET D'UN MATERIEL CENTRAL

摘要

Microspheres of core material and polymer are produced by adding a phase separation agent to a medium comprising a solution of the polymer and a solution or dispersion of the core material at a temperature of -40 to -100 DEG C. Preferably the core material is a drug and the polymer is biodegradable. The low temperature phase separation step prevents uncontrolled agglomeration of the microspheres.