| 摘要 |
<p>Heterocyclic guanidine derivatives of the formula I <IMAGE> in which the symbols are defined in Claim 1, and their pharmaceutically acceptable acid addition salts, are obtained by reacting a corresponding compound, possessing an alkylthio radical instead of the group -NR4R5, with an amine HNR4R5 in a lower aliphatic alcohol at reflux temperature and converting the resulting salt of the compound of the formula I into the free base and, where appropriate, preparing pharmaceutically acceptable acid addition salts from compounds obtained. The quaternary products can also be prepared. The compounds of the formula I, their salts and the quaternisation products, inhibit, for example, gastric juice secretion and lower blood sugar level. They can be used as medicaments.</p> |
