DERMATOLOGICAL COMPOSITIONS COMPRISING ACYLAMINO-CARBOXYLIC ACID DERIVATIVES

摘要

1436614 Dermatological compositions DR KARL THOMAE GmbH 16 July 1973 33699/73 Heading C2C [Also in Division A5] Compounds of the general formula wherein R 2 represents H or C 1 -C 3 alkyl; R 3 represents H, C 1 -C 6 alkyl which may be substituted by a methylthio group or a benzyl group; n represents 0, 1 or 2; and either R 1 represents H, trifluoromethyl or C 1 -C 4 alkyl and R 4 represents a straight- or branchedchain alkyl group with 8 to 24 carbon atoms; or R 1 represents a straight- or branched-chain alkyl group with 17 to 24 carbon atoms, a phenyl group optionally substituted by an alkyl group, a halogen atom or a nitro group, or a biphenyl group and R 4 represents H or a straight- or branched-chain alkyl group with 1 to 4 carbon atoms are prepared by acylating a compound of the general formula with a reactive derivative of an acid of formula R 1 -COOH. Glycine octadecyl ester is prepared by reacting glycine ethyl ester hydrochloride, octadecanol and hydrogen chloride.