| 摘要 |
Case 4-337/338/339 CANADA PROCESS FOR THE PRODUCTION OF A DERIVATIVE OF PHENYLACETIC ACID The present invention concerns a new process for the production of a derivative of phenylacetic acid, the o-(2,6-di-chloroanilino)-phenylacetic acid and its salts with bases which have strong antiinflammatory and antirheumatic activity. In this process a compound of the general formula I (I) wherein X represents the 2-furyl radical, an optionally acetalized 5-formyl-2-furyl radical or the vinyl radical, is subjected to an oxidative cleavage reaction and, if desired, the o-(2,6-dichloroanilino)-phenylacetic acid is converted into a salt with a base As an oxidant, e.g. ozone is used, if necessary followed by a further oxidant such as a permanganic acid salt or hydrogen peroxide. |
