| 摘要 |
1374943 Noracymethadol carbamates ELI LILLY & CO 22 Jan 1973 [25 Jan 1972] 3091/73 Heading C2C The novel compounds of Formula I wherein Y is O or S, R is C 1 -C 5 alkyl or phenyl and R<SP>1</SP> is CH 3 or C 2 H 5 , may be prepared by acylation or thioacylation of the corresponding noracetyl or norpropionyl methadol or Formula II wherein R<SP>1</SP> is as defined above, preferably using ethyl, n-butyl or sec-butyl chlorocarbamate.α-l-Noracetylmethadol is prepared by reaction ofα-l-acetylmethadol with diethylazodicarboxylate. Pharmaceutical compositions having analgesic activity for oral, intraperitoneal or subcutaneous administration comprise a compound of Formula I together with conventional extenders excipients or binders. |
