| 摘要 |
<p>9alpha-Unsubstd.-11beta-chloro-19-norsteroids having structure (I) in the D-ring. R1 = acyl such as OAc or acyloxyacetyl R2 = OH, acyloxy or H R3 = OMe; or R2 + R3 = single bond, epoxy or methylene, or form part of 1'-pyrazolino-(4',3':16alpha,17alpha) or 2'-pyrazolino-(4',5':16alpha,17alpha) gps. R4 = H or Me; or R3+R4 = methylene The following 11beta-chloro-19-norpregn-4-ene-3,20-diones:- 16alpha,17alpha-epoxy-16beta-Me; 16-ene; 16alpha-OMe; etc. The cpds. show antioestrogenic (no 17alpha-acyloxy) and progestinogenic (17alpha-acyloxy) activity when given orally or parenterally.</p> |
