Antiallergic and detoxicant mucoprotide from tissue autolysates - produced by precipitating proteins and treating with acetone

摘要

In the prepn., (a) a dil. aq. soln. of the mucoprotide components is produced by autolysis of the starting material, precipitating precipitable proteins with dilute lead acetate and dilute ammonium sulphate, and sepn. of the supernatant; (b) the aq. soln. is treated with acetone to form 3 layers; (c) the upper and middle layers are sepd. from the lower layer; (d) the two upper layers from (c) are heated to ppte unstable and antigenic substances; and (e) the ppte is sepd. off and discarded. A new mucoprotide prod. is produced from liver parenchyma, placenta, yeast or other natural sources and chiefly consists of protides such as protein and protein hydrolysates with a ca. 0.1-40% mucoid content. The mucoprotide shows a marked saddle in the IR spectrum at a wave number between ca. 1000 and 1200. T'e mucoprotide product is useful for the treatment of Allergies and hypersensitivities, toxic states, undesired side-effects of drugs, drug-dependence and alcoholism. It is particularly useful when the disorder to be treated is accompanied or caused by damaged liver function. The product may be administered orally or parenterally.