摘要 |
The present invention relates to new pharmacologically valuable derivatives of 1-phenoxy-3-amino-propan-2-ol having the formula <IMAGE> and the aldehyde condensation products and acid addition salts thereof wherein X is selected from the group consisting of <IMAGE> and <IMAGE> wherein the phenyl ring I may have attached to it up to three similar or different substituents selected from the group consisting of alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, alkoxy, alkenyloxy, alkinyloxy, benzyloxy, phenyl, halogen and -NR1R2, wherein R1 is selected from alkyl and acyl, and R2 is selected from hydrogen and alkyl; and to the production thereof by a method selected from (A) reacting 1-phenoxy-3-amino-propan-2-ol having the formula <IMAGE> with a compound having the formula Y-X, wherein X has the above-defined meaning and Y is selected from halogen, -OH, -OK or -ONa; (B) reacting a compound of the formula <IMAGE> with a compound of the formula H2N-X, wherein X has the above-defined meaning and Z is selected from <IMAGE> and <IMAGE> (C) reacting a phenol <IMAGE> wherein X and Z have the meaning defined above.
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申请人 |
CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT |
发明人 |
RAABE, THOMAS;GRAWINGER, OTTO;SCHOLTHOLT, JOSEF;NITZ, ROLF-EBERHARD;SCHRAVEN, ECKHARD |