METHOD FOR PRODUCING TRIFLUORO-3(R)-HYDROXYBUTYRIC ACID DERIVATIVES

摘要

The invention relates to a biotechnological method for producing trifluoro-3(R)-hydroxybutyric acid derivatives of the general formula (I), where R<1> represents -OR<2>, where R<2> is hydrogen, C1-10 alkyl, C1-10 alkenyl, C3-8 cycloalkyl, aryl, alkoxyalkyl or alkoxyalkoxyalkyl; -NR<3>R<4>, where R<3> and R<4> are the same or different and represent hydrogen, C1-10 alkyl, C1-10 alkenyl, C3-8 cycloalkyl or aryl; or -SR<5>, where R<5> represents hydrogen, C1-10 alkyl, C1-10 alkenyl, aryl or C3-8 cycloalkyl, based on a trifluoroacetoacetic acid derivative of the general formula (II), where R<1> has the meaning given above, by means of micro-organisms which are able to reduce a carbonyl function or by means of a cell-free enzyme extract of said micro-organisms.