| 摘要 |
<p>Prepn. of 6-aryl-4H-s-triazolo- 3,4-c thieno- 2,3-e -1,4-diazepines of formula (VII) and their acid addn. salts by a multistage process from cpds. (I) via novel thieno-4,1-oxa-zepines (II), including reaction of a later intermediate with R3CONHNH2. In the formulae, R1 and R2=H, halogen, 1-2C alkyl or together form a 5-6 membered ring; R3=H, Cl, Br 1-3C alkyl, 1-3C omega-hydroxy alkyl, 3-6C cycloalkyl or a 5- or 6-membered heterocycle contg. O, S or N and which may be substd. on the N by lower alkyl. R4 and R5=H, F, Cl or Br. X=halogen, amino or acyloxy. Cpds. (VII) are anticonvulsants, anxiolytics, and anti-aggressive agents.</p> |
