| 摘要 |
1,260,208. Gel filtration chromatography; dialysis membrane. MERCK PATENT G.m.b.H. 2 Dec., 1969 [15 Feb., 1969], No. 58828/69. Heading B1X. [Also in Division C3] Gel chromatographic separation of mixtures optionally performed under pressure may be effected using swellable polymers, in particulate form in the unswollen state or in the form of membranes e.g. planar or tubular and for dialysis or desalination, prepared by polymerising at least one diacrylate or dimethacrylate of an alkylene glycol or polyalkylene glycol or a triacrylate or trimethacrylate of a polyalkylene oxide triol, the alkylene groups containing 2 or 3 carbon atoms. Specified esters are of ethylene, diethylene, triethylene, tetraethylene and propylene glycols and glycerol/propylene oxide adducts; and cross-linking comonomers, e.g. other glycol acrylates and methacrylates, divinyl benzene, divinyl pyridine, divinyl ethers and esters, diallyl esters, diallyl sulphone and vinyl and allyl acrylic compounds, may also be used. Pore. formers, e.g. polystyrene and calcium carbonate, may be incorporated in the polymers and subsequently dissolved out. Examples describe polymers of (1 and 3) tetraethylene glycol dimethacrylate for the separation of polystyrenes and dextrans; (2 and 4) polyethylene glycol and ethylene glycol dimethacrylates for the separation of polystyrenes and polyethylene oxides; and (5) polyethylene glycol dimethacrylate for the separation of polystyrenes. Polypeptides and polynucleotides may also be separated. Further examples describe the preparation of particulate polymers from (6) polypropylene oxide triol trimethacrylate, (7) triethylene glycol dimethacrylate, (8) diethylene glycol dimethacrylate and (9) polyethylene glycol dimethacrylate and butane diol dimethacrylate; and membranes from (10-13) polyethylene glycol dimethacrylate. |
