发明名称 |
Novel antibacterial and herbicidal compounds and system for screening for the same |
摘要 |
A transgenic bacterial host cell that can be used as a screen for novel antibiotics and herbicides is provided. The genome of the transgenic bacterial host cell comprises disruptions in a first endogenous gene in the MEP pathway) and a transgene that functionally replaces the disrupted first gene. In other embodiments, the genome comprises a disruption in a first endogenous gene in the MEP pathway and a second endogenous gene which is located downstream of the first gene in the MEP pathway. A transgene that functionally replaces the disrupted downstream gene is cloned into the host cell. A mini operon containing the essential genes for the MVA pathway may also be cloned into the host cell. The transgenic host cell may be used in a method for screening compounds for antibiotic and herbicidal properties. The agents determined by the screening method may be used to kill bacteria or plants. |
申请公布号 |
AU1535202(A) |
申请公布日期 |
2002.04.22 |
申请号 |
AU20020015352 |
申请日期 |
2001.10.13 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
CHARLES POULTER;FREDERICK HAHN;RITA CORNISH;CHARLES TESTA |
分类号 |
C12N1/21;C12N9/88;C12Q1/04;C12Q1/18 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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