Dipyridodiazepinones as HIV reverse transcriptase inhibitors

摘要

Disclosed is a compound of formula I wherein R2 is H, halogen, alkyl, O-alkyl, NH-alkyl or N(alkyl)2; R4 is H or CH3; R5 is H or CH3, provided that R4 and R5 are not both the same; R12 is H, halogen, alkyl, CF3, or NO2; R13 is H, alkyl, halogen, OH, or NH2, with the proviso that R12 and R13 are not both H; and R14 is COOR14a, alkenyl-COOR14a or alkyl-COOR14a wherein R14a is H or alkyl. Compounds of the type disclosed are inhibitors of reverse transcriptase useful in the treatment and prevention of HIV infection.