INTERMEDIATES AND PROCESS FOR PRODUCING FLUORINE-CONTAINING AMINO ACID COMPOUND BY USING THE SAME

摘要

(1S,5R,6S)- or (1SR,5RS,6SR)-3-fluoro-2-oxobicylo[3.1.0]-hex-3-ene-6- carboxylic acid derivatives represented by general formula (1); a process fo r producing the same; and a process for efficiently producing a fluorine- containing amino acid compound acting on group 2 metabotropic glutamate receptor which has therapeutic and preventive effects on psychiatric disease s or neurological diseases, characterized by hydrogenating the above compound (1) and then further converting the same into hydantoin or amino cyanide followed by hydrolysis. In formula (1), R represents OR1 or NR1R2 (wherein R 1 and R2 are the same or different and each represents hydrogen, C1-6 alkyl, C 3- 6 cycloalkyl, (C3-6 cycloalkyl)(C1-6 alkyl), aryl, aryl(C1-6 alkyl), (C1-6 alkoxy)(C1-6 alkyl), C1-6 hydroxyalkyl, (C1-6 alkylthio)(C1-6 alkyl) or C1-6 mercaptoalkyl).