摘要 |
<p>A microparticle composition comprising a biodegradable polymer, an immunogenic single-stranded ribonucleic acid (ss-RNA) material, a biologically active macromolecule and a stabilising agent wherein the outer surface of the resulting microparticle is free from adsorbed molecules is described. The composition is effective in providing an immune response in dendritic cells, in particular by stimulating increased production of IFN-a. Methods of production and uses, in medicine, of pharmaceutical compositions derived from the microparticles are also claimed and described.</p> |
申请人 |
THE SECRETARY OF STATE FOR DEFENCE;EYLES, JAMES, EDWARD;WESTWOOD, ANGELA;ELVIN, STEPHEN, J.;HEALEY, GARETH, DAVID |
发明人 |
EYLES, JAMES, EDWARD;WESTWOOD, ANGELA;ELVIN, STEPHEN, J.;HEALEY, GARETH, DAVID |