发明名称 |
Peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity |
摘要 |
In one aspect, the present invention provides isolated novel peptides that can be used to modulate innate immunity in a subject and/or for the treatment of an immune-related disorder, including treating and preventing infection by modulating innate immunity. Also provided are an agent reactive with the peptide, a pharmaceutical composition that includes the peptide, an isolated nucleic acid molecule encoding the peptide, a recombinant nucleic acid construct that includes the nucleic acid molecule, at least one host cell comprising the recombinant nucleic acid construct, and a method of producing the peptide using the host cell. The present invention further provides a method for treating and/or preventing infection in a subject by administering the peptide of the invention to the subject, thereby modulating innate immunity in the subject. Additionally, the present invention provides a method for predicting whether a subject would be responsive to treatment with a peptide of the invention. |
申请公布号 |
US9416157(B2) |
申请公布日期 |
2016.08.16 |
申请号 |
US201213360163 |
申请日期 |
2012.01.27 |
申请人 |
Soligenix, Inc. |
发明人 |
Donini Oreola;Rozek Annett;Lentz Shannon Wayne |
分类号 |
C07K7/06;C07K7/64;C07K7/00;C07K7/08;C12Q1/37;G01N33/569;C07K7/54;A61K38/00 |
主分类号 |
C07K7/06 |
代理机构 |
Lewis Kohn & Walker LLP |
代理人 |
Lewis Kohn & Walker LLP ;Kohn David M.;Moyer-Henry Kari |
主权项 |
1. An isolated peptide consisting of up to 7 amino acids, said peptide comprising the amino acid sequence of X1X2X3P (SEQ ID NO: 56), wherein:
X1 is R; X2 is I or V, wherein X2 can be N-methylated; X3 is I or V; wherein X3 can be N-methylated; P is proline or a proline analogue; wherein SEQ ID NO: 56 is the first four amino acids at the N-terminus of the peptide; or a pharmaceutical salt, ester or amide thereof. |
地址 |
Princeton NJ US |