发明名称 |
TRIPTERYGIUM WILFORDII HOOK F EXTRACTS AND COMPONENTS THEREOF FOR IMMUNOSUPPRESSION |
摘要 |
The present invention involves the use of Tripterygium Wilfordii Hook F extracts in the treatment of rheumatoid arthritis. An alcohol extract of this plant (T2) inhibited antigen- and mitogen-stimulated proliferation of T cells and B cells, cell cycle progression, interleukin-2 (IL-2) production by T cells, immunoglobulin production by B cells and interleukin-2 mRNA production. T2 did not affect IL-2 receptor expression by T cells, IL-1 production by monocytes, the capacity of monocytes to present antigen, or signaling pathways. Inhibition could not be accounted for by nonspecific toxicity. These results support the conclusion that T2 exerts a powerful suppressive effect on human immune responses. Suppressing autoimmune disease is a most preferred embodiment of this invention. |
申请公布号 |
AU7570191(A) |
申请公布日期 |
1991.10.10 |
申请号 |
AU19910075701 |
申请日期 |
1991.03.14 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
PETER E LIPSKY;XUE-LIAN TAO |
分类号 |
A61K31/365;A61K31/44;A61K31/565;A61K36/00;A61K36/37;C12Q1/68 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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