| 摘要 |
<p>The invention relates to the use of omega chain modified prostaglandins as ocular hypotensive. The derivatives used in accordance with the invention are encompassed by structure formula (I): wherein the hatched segments represent α bonds; the wavy segments represent an α or β bond; dashed lines represent a double bond or a single bond; X is selected from the group consisting of -OR and N(R2); Y is = O or represents 2 hydrogen radicals, provided that Y represents 2 hydrogen radicals when X is OH; R is hydrogen or a lower radical having up to six carbon atoms; R is = O or hydroxy; m is = 0, 2, 4 or 6, provided that m is not 4 when the wavy segment represents a β bond; n is 0, 2, 4 or 6, x and y are 0 or 1, provided that x is 1 when y is 0 and y is 1 when x is 0; or 9, 11 and/or 15 ester derivatives of said compounds of formula (I), e.g. a C1 and C6 alkyl ester derivative; or a pharmaceutical acceptable salt thereof.</p> |
