发明名称 |
HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3) AND USES THEREOF -3(LAG-3) |
摘要 |
The present disclosure provides isolated human monoclonal antibodies and antigen-binding portions thereof that bind to human LAG-3, in particular antibodies and antigen-binding antibody portions that can inhibit the binding of LAG-3 to MHC Class II molecules and that can stimulate antigen-specific T cell responses. Nucleic acid molecules encoding the antibodies and antigen-binding antibody portions of the invention as well as compositions and immunoconjugates of the antibodies and antigen-binding antibody portions of the invention are also provided. This disclosure also provides for the use of the antibodies and antigen-binding antibody portions of the invention in therapy. |
申请公布号 |
HK1212911(A1) |
申请公布日期 |
2016.06.24 |
申请号 |
HK20160100937 |
申请日期 |
2016.01.28 |
申请人 |
E. R. Squibb & Sons L.L.C. |
发明人 |
Kent B. THUDIUM;Alan J. KORMAN;Heidi LEBLANC;Mark YAMANAKA;Mark SELBY;Kyra D. ZENS |
分类号 |
A61K;C07K |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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