METHOD OF PREPARING N-CYANO-N-METHYL-N'-(2-(5-METHYLIMIDAZOL-4-IL)-METHYLTHIO)ETHYL GUANIDINE

摘要

Title compd.(I) was prepd. by comdensation reaction of N''-cyano-N-methy -N'-(2-m rcaptoehyl)guanidine(III) and 5-methyl-4-chloromethylidazole(II) in the presence of ter-kalium butoxide. III was prepd. by reaction of compd. IV(x= Cl2;Br) and V in alcohol soln. at room temp. Thus, 10.2 g IV, 8.5 g V and 2 g sodium hydroxide were reacted in 100ml methanol at room temp. for 12 hr. obtained 4.2 g liq. residue and 4.4 butoxide for 2hr to give 3.8 g I.