MODULATION OF CYTOKINE PATTERNS OF HUMAN AUTOREACTIVE T-CELL CLONES

摘要

The present invention relates to methods and compositions for altering the cytokine pattern of activated autoreactive T-cells, particularly inflammation-promoting T-cells in patients afflicted with an autoimmune disease, and for diminishing immune responses associated with autoimmune disease. The invention includes a method to alter the cytokine pattern from a first pattern that promotes immune responses, Th0, to an altered version of the first pattern that downregulates immune responses.