| 摘要 |
PURPOSE:To obtain an agent for introducing differentiation of tumor cell, having low influence on calcium metabolism in organisms, by adding 9,10-seco-5,7,10(19)- pregnatriene derivative as an active ingredient. CONSTITUTION:A novel 9,10-seco-5,7,10(19)-pregnatriene derivative shown by the formula (R1, R2 and R3 are H or OH; R4 is 4-8C lower alkyl which may be replaced with H or OH) as an active ingredient is pharmaceutically manufactured into the form of oral agent, injection etc., by a conventional procedure to give the aimed substance. A dose is 0.01-10mug, preferably 0.1-5mug per adult daily. An agent for introducing differentiation of tumor cell, to be concrete, is effective for treating tumor such as myelogenic leukemina, etc. The compound shown by the formula, for example, is synthesized from pregnenolone or dehydroepiandrosterone as a raw material.
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