PEPTIDYL COMPOUNDS COMPRISING AN ITIM MOTIF WHICH REGULATE HEMATOPOIETIC FUNCTION AND THEIR USE

摘要

The present invention is directed to a novel product and method for regulating hematopoietic cell function and a novel product and method for identifying compounds capable of regulating inflammation. The present invention includes a method to regulate hematopoietic cell function by contacting a cell with a regulatory reagent capable of altering the activity of a molecule including PTP1C, PTP1D, ITIM-p160 and ITIM-p70. The present invention also relates regulatory reagents capable of regulating the activity of PTP1C, PTP1D, ITIM-p160 and ITIM-p70, including nucleic acid molecules having sequences that encode such reagents and antibodies raised against such reagents. The present invention also includes a therapeutic composition comprising such reagents and their use to protect animals from inflammation.