发明名称 |
1-Substituted glycopyranosides |
摘要 |
The invention disclosed herein relates to novel 1-deoxy-glycopyranosides, preferably 1-deoxy-D-mannopyranosides, having in the 1-position of the pyranoside ring an omega -aminoalkylthio, omega -aminoalkyloxy or omega -aminoalkanoylamino substituent; and to novel processes for preparing these 1-substituted-1-deoxy-glycopyranosides starting with the corresponding tetra-O-acetyl-glycopyranosyl bromide or amine. These omega -amino(alkylthio, alkyloxy or alkanoylamino)-1-deoxy-glycopyranosides, and in particular 1-[(6'-aminohexyl)thio or oxy]-1-deoxy-D-mannopyranosides, possess insulin-like activity.
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申请公布号 |
US4228274(A) |
申请公布日期 |
1980.10.14 |
申请号 |
US19780922897 |
申请日期 |
1978.07.10 |
申请人 |
MERCK & CO., INC. |
发明人 |
PONPIPOM, MITREE M.;BUGIANESI, ROBERT L.;DURETTE, PHILIPPE L.;KATZEN, HOWARD M.;SHEN, TSUNG-YING |
分类号 |
C07H13/04;C07H15/04;C07H15/14;(IPC1-7):C07H5/06;C07H5/08 |
主分类号 |
C07H13/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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