New imidazoline derivatives having affinity for the imidazoline receptor

摘要

Imidazoline derivatives of formula (I), their isomers and acid addition salts are new. R =1-(R1)-2-(R2)-3-(R3)-4-(R4)-5-(R5)-6-(R6)-phenyl, naphthyl substituted by R6, indol-5-yl, 1-phenyl-1-cyclohexylmethyl, cycloheptyl, 4-(benzothiazol-2-yl)benzyl or group of formula (i); R1 = 1-6C alkyl; and R2, R3, R5 = H and R4 = halo; or R2, R4, R5 = H; and R3 = halo other than Cl; or R2 = CN and R3-R5 = H; or R1 = halo; and R2, R4, R5 = H; and R3 = halo other than R1; or R2, R3, R5 = H; and R4 = 1-6C alkyl; or R1 = H; and R2-R4 = H and R5 = phenyl; or R2, R3 = two different halo; and R4, R5 = H; or R2 = halo, 2-6C alkyl or 1-6C alkylcarbonyl; and R3-R5 = H; or R2, R4, R5 = H; and R3 = ethyl, n-propyl, n-butyl, CF3, 1-6C alkylthio, CF3O, phenyl, phenoxy, 1-6C acylamino, aminosulphonyl (optionally N-substituted by 1 or 2 1-6C alkyl groups); or R2 = NO2; R3 = OH; R4 = halo; and R5 = H; or R3, R5 = H; and R2, R4 = halo (provided that they are not both Cl).