发明名称 |
Vectors and compounds for expression of human protein C |
摘要 |
The present invention comprises novel DNA compounds which encode human protein C activity. A variety of eukaryotic and prokaryotic recombinant DNA expression vectors have been constructed that comprise the novel protein C activity-encoding DNA and drive expression of protein C activity when transformed into an appropriate host cell. The novel expression vectors can be used to produce protein C derivatives, such as non-carboxylated, non-glycosylated, or non-hydroxylated protein C, and to produce protein C precursors, such as nascent or zymogen protein C, and to produce subfragments of protein C, such as active or inactive light and heavy chain. The recombinant-produced protein C activity is useful in the treatment and prevention of a variety of vascular disorders.
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申请公布号 |
US5270040(A) |
申请公布日期 |
1993.12.14 |
申请号 |
US19920907499 |
申请日期 |
1992.07.01 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
BANG, NILS U.;BECKMANN, ROBERT J.;JASKUNAS, S. R.;LAI, MEI-HUEI T.;LITTLE, SHEILA P.;LONG, GEORGE L.;SANTERRE, ROBERT F. |
分类号 |
C12N9/64;(IPC1-7):A61K37/547 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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