摘要 |
This invention provides compositions for use in distributing active agents for treating a malignant tumor in a subject. The compositions contain RNAi molecules targeted to a human GST-π, along with RNAi molecules targeted to a human p21, and a pharmaceutically acceptable carrier. The carrier can include nanoparticles composed of an ionizable lipid, a structural lipid, one or more stabilizer lipids, and a lipid for reducing immunogenicity of the nanoparticles. This invention further provides methods for preventing or treating a malignant tumor by administering a therapeutically effective amount of an RNAi composition |
申请人 |
NITTO DENKO CORPORATION;YING, WENBIN |
发明人 |
YING, WENBIN;NIITSU, YOSHIRO;MINOMI, KENJIROU;MAJETI, BHARAT;WANG, LI;LIU, JIHUA;ADAMI, ROGER |