PROCESS FOR THE PREPARATION OF PANTOPRAZOLE SODIUM
摘要
A one-pot process for the preparation of pantoprazole sodium by reacting 2-chloro methyl 3, 4 - dimethoxy pyridine hydrochloride with 2-mercapto-5-difluoromethoxy benzimidazole in an organic solvent system in presence of a phase transfer catalyst and further treating with aqueous sodium hypohalite solution comprising sodium hydroxide to obtain pantoprazole sodium in high yield and purity. The process for conversion of pantoprazole sodium to pantoprazole sodium sesquihydrate and also pantoprazole sodium monohydrate are also disclosed herein.
申请公布号
WO2006064249(A3)
申请公布日期
2006.10.05
申请号
WO2005GB04861
申请日期
2005.12.15
申请人
CIPLA LIMITED;WAIN, CHRISTOPHER, PAUL;KANKAN, RAJENDRA, NARAYANRAO;SRINIVAS, PATHI, L.