| 摘要 |
The present invention discloses improved methods of disaggregating protein aggregates, and refolding denatured proteins, using high pressure. In particular, the present invention provides for the use of agitation, high temperature, "stepped" depressurization, dialysis and dilution under pressure to increase the speed and extent of aggregate dissolution and protein refolding. |
| 申请人 |
UNIVERSITY TECHNOLOGY CORPORATION;RANDOLPH, THEODORE, W.;CARPENTER, JOHN, F.;ST. JOHN, RICHARD, J.;WEBB, JONATHAN, N. |
发明人 |
RANDOLPH, THEODORE, W.;CARPENTER, JOHN, F.;ST. JOHN, RICHARD, J.;WEBB, JONATHAN, N. |
