NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

摘要

Pyridazine derivatives represented by general formula (1) or salts thereof, wherein R<1> represents lower alkoxy, lower alkylthio or halogeno; R<2> represents H, lower alkoxy, lower alkylthio or halogeno; R<3> represents OH, CN, halogeno, lower cycloalkyl, lower alkyl or lower alkenyl optionally substituted by an optionally substituted aromatic group or optionally substituted carbamoyl; R<4> represents COOH, lower alkoxycarbonyl, optionally substituted carbamoyl, optionally substituted amino or optionally substituted ureido; and the broken line means a single bond or a double bond between the carbon atoms at the 4- and 5-positions. Because of having an excellent effect of regulating interleukin-1 beta production, these compounds are useful as preventives/remedies for immunologic diseases, inflammatory diseases, ischemic diseases, etc.