Preparation of (S)-2-amino-6, 6-dimethoxyhexanoic acid methyl ester via novel dioxolanes

摘要

The glycinamide of the formula (I) is reacted with the dioxolane of the formula (II) wherein L is a leaving group such as iodo, bromo, alkylsulfonyloxy, or arylsulfonyloxy to give the dioxolane of the formula (III) Treatment of (III) gives the dioxolane pentanoic acid IV which can be converted to (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester.