| 发明名称 |
Appetite stimulating protein |
| 摘要 |
An engineered polypeptide comprising an AgRP analog with increased basic residues compared to the wild type polypeptide, wherein the polypeptide, when introduced into the CNS of a mammal, stimulates appetite. |
| 申请公布号 |
US9394343(B2) |
申请公布日期 |
2016.07.19 |
| 申请号 |
US201214130916 |
申请日期 |
2012.07.04 |
| 申请人 |
The Regents of the University of California |
发明人 |
Madonna Michael;Benoit Stephen;Millhauser Glenn |
| 分类号 |
A61K38/00;C07K16/00;C07K14/00;C07K14/47 |
主分类号 |
A61K38/00 |
| 代理机构 |
|
代理人 |
Bell Adam Warwick;Kaser Matthew Rupert |
| 主权项 |
1. An engineered polypeptide comprising a non-naturally occurring AgRP analog with increased positive charge compared to the wild type AgRP polypeptide, wherein the polypeptide is engineered to include one or more amino acid alterations within one or both of the N-terminal extension and the C-terminal loop, wherein the polypeptide is engineered to include amino acid alterations in the Ser-Ser-Arg-Arg N-terminal extension, and wherein the Ser-Ser-Arg-Arg N-terminal extension is altered to provide additional basic, positively charged amino acid residues beyond those found in wild type AgRP. |
| 地址 |
Oakland CA US |
