发明名称 |
METHOD FOR PRODUCING HEPATITIS B VIRUS PROTEINS IN YEAST |
摘要 |
The entire hepatitits B virus pre-S antigen gene linked in one contiguous reading frame to the hepatitis B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the expression of pre-S domains. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections. |
申请公布号 |
PH25249(A) |
申请公布日期 |
1991.03.27 |
申请号 |
PH19730000347 |
申请日期 |
1987.01.27 |
申请人 |
MERCK & CO.INC. |
发明人 |
RONALD W. ELLIS;ARPI HAGOPIAN;PETER J. KNISKERN |
分类号 |
C12N15/09;A61K39/29;C07K1/22;C07K14/00;C07K14/02;C07K14/10;C07K14/18;C12N1/16;C12N1/19;C12N15/00;C12N15/81;C12P21/00;C12P21/02;C12R1/645;C12R1/85 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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