Transdermal patch incorporating active agent migration barrier layer

摘要

Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.

主权项

1. A storage-stable device for the release of an active agent to the skin or mucosa of a host, the device comprising:
an outer patch including an adhesive layer; an outer patch release layer of an active agent impermeable material releasably adhered to the adhesive layer of the outer patch, the outer patch release layer including an opening exposing a portion of the adhesive layer, the outer patch release layer being removable prior to the application of the device to the skin or mucosa of a host; an inner patch comprising an active agent layer supported on an active agent impermeable backing layer, the active agent impermeable backing layer supported on the outer patch release layer overlying the opening therein, the active agent layer containing an active agent for administration to the skin or mucosa of a host; wherein a portion of the active agent impermeable backing layer of the inner patch is adhered directly to the adhesive layer exposed through the opening prior to and after removal of the outer patch release layer for application of the device to the skin or mucosa of a host; and wherein a remaining portion of the active agent impermeable backing layer is unadhered to the adhesive layer as a result of the outer patch release layer being interposed therebetween prior to removal for application of the device to the skin or mucosa of a host, wherein the outer patch has a surface area greater than a surface area of the inner patch, such that removal of the outer patch release layer for application of the device adheres the remaining portion of the active agent impermeable backing layer directly to a portion of the adhesive layer of the outer patch while exposing another portion of the adhesive layer of the outer patch extending beyond a periphery of the inner patch for adhering the device to the skin or mucosa of a host.