| 摘要 |
Compounds of the formula <IMAGE> (I) <IMAGE> in which the index n represents an integer of from 1 to 4, the index m represents 0 or 1, X represents oxygen, sulphur or the group -NH-, W represents a group -CO-, -CO-NHSO2- or -SO2NH-CO-, or X-W together represent a group -CO- or -CO-NHSO2-, A represents optionally substituted phenylene, thienylene or furylene, Z represents oxygen or sulphur, Y represents lower alkylene, the index k represents the value 1 or 2, R4 represents hydrogen, an optionally substituted lower aliphatic or cycloaliphatic radical or acyl, R1 represents hydrogen, lower alkyl, lower alkoxy, halogen or a group of the formula -CH2-R2 in which R2 represents a free, esterified or etherified hydroxy or mercapto group or a quaternary ammonium group, and R3 represents hydrogen or methoxy, and in which the carboxyl groups are optionally esterified in a form that can be split under physiological conditions, and salts of such compounds having salt-forming groups, are obtained by liberating the functional group(s) in a compound of the formula I in which at least one of the functional groups present is protected. The compounds are effective in vitro and in vivo against gram-positive and gram-negative bacteria and cocci.
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