| 主权项 |
1. A pen-injector device containing a liquid pharmaceutical formulation comprising an isolated IL-6 antibody having a light chain variable region and a heavy chain variable region, said light chain variable region comprising:
a complementarity determining region light chain 1 (CDRL1) amino acid sequence of SEQ ID NO:132 comprising the sequence S-X1-X2-X3-X4-V-X5-Y-M-Y, wherein X1 is A or G, X2 is S or R, X3 is H, I, S, or Y, X4 is S or Y, and X5 is S or F; a CDRL2 amino acid sequence of SEQ ID NO:133 comprising the sequence D-X6-S-X7-L-X8-S, wherein X6 is F, L, M, or T, X7 is N or E, and X8 is A or T; and a CDRL3 amino acid sequence of SEQ ID NO:134 comprising the sequence X9-X10-W-S-G-Y-P-Y-T, wherein X9 is M, C, or S, and X10 is Q or C; said heavy chain variable region comprising: a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence of SEQ ID NO:135 comprising the sequence G-F-X11-X12-S-X13-F-A-X14-S, wherein X11 is T or Q, X12 is F, S, or T, X13 is S or P, and X14 is L or M; a CDRH2 amino acid sequence of SEQ ID NO:136 comprising the sequence K-X15-S-X16-G-G-S-X17-X18-Y-X19-X20-D-T-X21-X22-X23, wherein X15 is A or I, X16 is S or P, X17 is Y or W, X18 is T, E, or Y, X19 is Y or F, X20 is P, S, D, or F, X21 is V or D, X22 is T or A, and X23 is G or P; and a CDRH3 amino acid sequence of SEQ ID NO:137 comprising the sequence Q-L-W-G-X24-Y-A-L-D-X25, wherein X24 is S, Y, T, or N, and X25 is Y, T, F, or I. |
