发明名称 |
Isolated p27 protein and methods for its production and use |
摘要 |
An isolated protein designated p27 is disclosed. The p27 protein has an apparent molecular weight of about 27 kD, and is capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. A nucleic acid sequence encoding p27 protein is disclosed, as well as a method for producing p27 in cultured cells. In vitro assays for discovering agents which affect the activity of p27 are also provided. Methods of diagnosing and treating hypoproliferative disorders are provided.
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申请公布号 |
US2002110886(A1) |
申请公布日期 |
2002.08.15 |
申请号 |
US20010865018 |
申请日期 |
2001.05.24 |
申请人 |
MASSAGUE JOAN;ROBERTS JAMES M.;KOFF ANDREW;POLYAK KORNELIA |
发明人 |
MASSAGUE JOAN;ROBERTS JAMES M.;KOFF ANDREW;POLYAK KORNELIA |
分类号 |
C07K14/47;(IPC1-7):C12N9/99;C07H21/04;C12P21/02;C12N5/06 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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