Predictive method of characterizing the radiosensitivity and tissular reaction of a patient to therapeutic ionizing radiation

摘要

The invention relates to a method of characterizing the cellular reaction of a cell sample to ionizing radiation, the cell sample having been obtained from cells taken from a non-irradiated or slightly irradiated region of a patient, and the method involving the following steps: (i) amplifying the sampled cells, the amplified cells constituting "the cell sample"; (ii) determining on the cell sample the mean number of nuclear foci obtained with at least two of the markers pH2AX, pATM and MRE11 at observation times t (these mean numbers being designated N