| 发明名称 |
HYDROXAMIC ACID AND HYDROXYUREA DERIVATIVES AND METHODS OF THEIR SYNTHESIS |
| 摘要 |
FIELD: organic chemistry. SUBSTANCE: invention describes compounds of the formula (I) <EMI ID=0.270 HE=33 WI=39 TI=CHI> where X - oxygen, chemical bond or NR ; Z - oxygen or sulfur. These compounds are inhibitors of lipoxygenase and useful as active agents in pharmaceutical compositions for treatment of inflammatory states in human and other mammalians caused by activity of lipoxygenase. EFFECT: improved method of synthesis. 16 cl, 1 tblh
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| 申请公布号 |
RU2108324(C1) |
申请公布日期 |
1998.04.10 |
| 申请号 |
RU19920016453 |
申请日期 |
1991.04.18 |
| 申请人 |
PFAJZER INK. |
发明人 |
RODNI UILL'JAM STIVENS;TAKAFUMI IKEDA;KHIROAKI VAKABAJJASI;MASAMI NAKANE;RODNI UILL'JAM STIVENS;TAKAFUMI IKEDA;KHIROAKI VAKABAJJASI;MASAMI NAKANE |
| 分类号 |
A61K31/16;A61K31/17;A61K31/47;A61P9/00;A61P29/00;A61P37/08;A61P43/00;C07C259/06;C07C275/64;C07C311/06;C07C323/41;C07C323/60;C07D213/64;C07D213/69;C07D215/12;C07D215/14;C07D215/18;C07D215/20;C07D277/34;C07D309/12;C07D311/58;C07D311/60;C07D317/64;C07D401/06;C07D409/06;(IPC1-7):C07C275/64;A61K31/19 |
主分类号 |
A61K31/16 |
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