| 摘要 |
5-Haloalkyl-2-(phenyl or benzoheterocyclyl)-pyridazin-3(2H)-one or -thione derivatives of formula (I) and their salts and stereoisomers are new: R1 = H, halo, 1-3C alkyl, 1-3C haloalkyl, alkoxyalkyl or cycloalkyl; R2 = 1-2C haloalkyl; R3 = H, halo, 1-3C alkyl or 1-3C haloalkyl; W = group of formula (W1)-(W3); R4 = H, F, Cl, Br or Me; R5 = H, halo, Me, etc.; R6 = H, halo, CN, NO2, NH2, SO2Cl, NHR10, NR10R11, OR20, -S(O)mR30, -SO2NR33R34, COR40, -COYR50 or -B-B'; R10,R11 = 1-8C alkyl, alkenyl, alkynyl, etc.; R20 = H, 1-8C alkyl, alkenyl, etc.; or alkyl-C(Q)-(1-8C) alkyl-; phenyl, benzyl, pyridyl, pyrimidinyl, pyrazinyl or pyridazinyl (all optionally ring-substituted by 1-3 of alkyl, haloalkyl and halo); 1-8C alkyl substituted by R21XCO-; or 1-6C alkyl substituted by R21XCO and phenyl; X = O, S or R22N; R21 = H, 1-8C alkyl, alkenyl, etc.;R22 = H, 1-8C alkyl or alkenyl; m = 0-2; R30 = H, 1-8C alkyl, alkenyl, etc.;or R31VC(O)-alkyl; V = O, S or NR32; R31 = H, 1-8C alkyl, alkenyl, etc.;R32 = e.g. H; R33 = alkynyl or as R32; R34 = alkylcarbonyl or as R33; R40 = H, Cl, 1-8C alkyl, etc.; Y = O, S, NR51 or NOR54; R50 = e.g. H; R51,R53 = e.g. 1-8C alky; R54,R55 = alkyl; B = H, R52ZC(O)-, CN or alkylcarbonyl; X1,X2 = O or S; R60 = H or alkyl; R61 = H, 1-6C alkyl, cycloalkyl, 3-6C alkenyl, etc.; n' = 0-4; R70 = H, halo, CF3, etc.; O-A1-B1 = O-CR71R72-CH2 or O-C(R72)=CH; R71 = H or 1-6C alkyl; R72 = H, CN, 1-6C alkyl, 1-6C haloalkyl, cyanoalkyl, etc., NR73R74CO-, phenoxycarbonyl or phenyl-(1-6C)alkyl (both optionally substituted by 1-3 of halo, alkyl and haloalkyl), NH2CS- or -CHO; R73 = e.g. H or 1-6C alkyl; R74 = as R73 or phenyl (optionally substituted by 1-3 of halo, alkyl and haloalkyl); Q = e.g. O; B' = e.g. 1-8C alkyl; Q' = e.g. OH; unless specified otherwise alkyl moieties have 1-4C, alkenyl or alkynyl moieties have 3-8C and cycloalkyl or cycloalkenyl moieties 3-6C.
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