Uridine diphosphate compounds as mobilizers of hematopoietic progenitor cells

摘要

The present invention provides for compositions and methods for administering one or more UDP compound, alone or in combination with another hematopoietic progenitor cell mobillizing compound (for example, but not limited to G-CSF), to mobilize hematopoietic progenitor cells for transplant or other purposes. The methods of the invention may be particularly advantageous as applied to improve the stem cell yield in so-called “poor mobilizing” patients.

主权项

1. A method of mobilizing hematopoietic stem progenitor cells from the bone marrow into the peripheral circulation of a subject in need thereof, comprising administering to the subject an effective amount of a uridine diphosphate (UDP) compound.