Antibodies specific for trop-2 and their uses

摘要

The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.

主权项

1. An isolated polynucleotide comprising a nucleotide sequence encoding an antibody which specifically binds to trophoblast cell-surface antigen-2 (Trop-2), wherein the antibody comprises:
(a) a heavy chain variable (VH) region comprising complementarity determining region one (CDR1), CDR2, and CDR3 of the VH sequence shown in SEQ ID NO: 4 or 5; and (b) a light chain variable (VL) region comprising CDR1, CDR2, and CDR3 of the VL sequence shown in SEQ ID NO: 3, 6, or 7.