发明名称 |
Method for separation of enantiomeric isomers by simulated moving bed chromatography |
摘要 |
The present invention provides a method having a high productivity for preparative separation by simulated moving bed chromatography. That is, in a filler for enantiomeric isomer separation by simulated moving bed chromatography, which has a porous carrier carrying a polysaccharide derivative thereon and has a TS coefficient in a range of 0.55 to 1.20, the TS coefficient being defined by the below-shown formula (I), and obtained by using an enantiomeric isomer separation column for simulated moving bed chromatography in which the filler is filled in a column tube by a slurry filling method: <?in-line-formulae description="In-line Formulae" end="lead"?>TS coefficient=[Vc-[t(TS)-t(blank)]xFR]/[t(TS)-t(blank)]xFR, (I)<?in-line-formulae description="In-line Formulae" end="tail"?> wherein Vc (cm<SUP>3</SUP>): a column volume; FR (ml/min.): a flow velocity; t(TS) (min.): an elution time for tetrakis(trimethylsilyl)silane (=TS); and t(blank) (min.): an elution time for TS in the state where the column is not connected.
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申请公布号 |
US7306734(B2) |
申请公布日期 |
2007.12.11 |
申请号 |
US20040943436 |
申请日期 |
2004.09.17 |
申请人 |
DAICEL CHEMICAL INDUSTRIES, LTD. |
发明人 |
OHNISHI ATSUSHI;MURAZUMI KOICHI |
分类号 |
B01D15/08;B01J20/291;B01D15/00;B01D15/18;B01D15/20;B01D15/22;B01D15/38;B01J20/281;B01J20/283;B01J20/29;B01J20/32;C07B57/00;G01N30/04;G01N30/26;G01N30/46;G01N30/56;G01N30/74;G01N30/88 |
主分类号 |
B01D15/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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